Synthesis of Naproxen Esters and Evaluation of their In vivo and In silico Analgesic and Anti-inflammatory Activities

Three consecutive alkyl esters methyl (1), ethyl (2) and isopropyl (3) were synthesized from naproxen by direct Fischer esterification reaction evaluated for their in vivo silico analgesic antiinflammatory activities. Methyl ester showed potent peripheral analgesia with 82.09% 82.59% writhing inhibition, respectively compared to that of (64.68% inhibition) at equivalent dose 25 mg/kg bw. In study, all the three generated 96.75%, 91.54% 90.65% inhibition inflammation 5th hour, similar obtained (95.12% inhibition). Molecular docking study suggested had highest binding energy towards COX-2 enzyme, while possessed lowest energy, also exhibited lower Vander Waals interaction might affect COX inhibition. Moreover, compounds satisfactory ADME profile. Again, satisfied safety issues, other have cardio toxicity. Dhaka Univ. J. Pharm. Sci. 22(1): 105-114, 2023 (June)